Multimeric Biotherapeutics, Inc.

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Publications on MegaCD40L™:

Design of CD40 Agonists and their use in growing B cells for cancer immunotherapy. R.S. Kornbluth, M. Stempniak, G.W. Stone. Int Rev Immunol 31(4):279-288, 2012.

Multimeric soluble CD40 ligand (sCD40L) efficiently enhances HIV specific cellular immune responses during DNA prime and boost with attenuated poxvirus vectors MVA and NYVAC expressing HIV antigens. C.E. Gomez et al., Vaccine 27:3165-74, 2009.

A soluble hexameric form of CD40 ligand activates human dendritic cells and augments memory T cell response. I. Miconet and G. Pantaleo, Vaccine 26:4006-14, 2008.

Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. W. Tu et al., Blood 112:2554-62, 2008.

Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex N. Holler et al., Mol Cell Biol 23:1428-40, 2003.

IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD+IgM+, post-germinal center (CD27+) human B cells. Werner-Favre et al., Eur J Immunol 31:243-249, 2001.

Publications on UltraCD40L™ and Other UltraLigands™:

HIV-1 adenoviral vector vaccines expressing multi-trimeric BAFF and 4-1BBL enhance T cell mediated anti-viral immunity S. Kanagavelu et al. PLoS One. 2014 Feb 28;9(2):e90100.

Vaccination with a fusion protein that introduces HIV-1 Gag antigen into a multi-trimer CD40L construct results in enhanced CD8+ T cell responses and protection from viral challenge by vaccinia-Gag S.Gupta et al. J Virol 88:1492-1501, 2014.

Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine S.K. Kanagavelua et al. Vaccine 30:691-702, 2012.

Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-like receptor agonists as a treatment for melanoma G.W. Stone et al., PLoS ONE 4(10): e7334, 2009.

Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines G.W. Stone et al., J Virol 80:1762-1772, 2006.

Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro G.W. Stone et al., Clin Vaccine Immunol 13:1223-1230, 2006.

Immunostimulatory combinations: designing the next generation of vaccine adjuvants R.S. Kornbluth and G.W. Stone. J Leukocyte Biol 80: 1084-1102, 2006.

Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154 L.E. Haswell, M.J. Glennie, and A. Al-Shamkhani, Eur J Immunol 31:3094-3100, 2001.